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KMID : 0605620060130030170
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Journal of Korean Society of Biological Psychiatry
2006 Volume.13 No. 3 p.170 ~ p.177
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Association between Social Phobia and Serotonin Transporter Gene Polymorphism : Preliminary Study
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Lee Jae-Hon
Lim Se-Won
Oh Kang-Seob
Lee Min-Soo
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Abstract
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ele frequency analysis, a significant association was also observed between the short allele and social phobia(p=.030). A significant associations between S genotype and each subgroup were observed(GEN p=.045 ; NGEN p=.033), but there were no differences in allele frequency. And, no differences in genotype and allele distribution between two subgroups were found. CONCLUSION: The results in our Korean sample suggest that S genotype of 5-HTTLPR may be associated with social phobia and s allele may be an important genetic factor that activates social phobic symptoms. But, further studies including large number of samples are necessary to elucidate these present findings.
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KEYWORD
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Social phobia, Serotonin transporter(5-HTT), Polymorphism
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